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Collaborative Research Centre (CRC) 1270 ‘Electrically Active ImplanNts – ELAINE’
​​​​​​​18 Doctoral researcher - 6 Post Doc – and 3 Short-Term Research Fellowship available at the Collaborative Research Centre (CRC) 1270 ‘Electrically Active ImplanNts – ELAINE’
Collaborative Research Centre (CRC) 1270 ‘Electrically Active ImplanNts – ELAINE’
European populations are ageing rapidly. By the year 2060, every third person living in Germany will be older than 65. For this reason, the social and socio-economic relevance of regenerative therapies is clearly increasing.
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Standort: Rostock, Deutschland
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​​​​​​​18 Doctoral researcher - 6 Post Doc – and 3 Short-Term Research Fellowship available at the Collaborative Research Centre (CRC) 1270 ‘Electrically Active ImplanNts – ELAINE’

ELAINE focuses on novel electrically active implants - specifically implants employed for the regeneration of bone and cartilage, and implants for deep brain stimulation to treat movement disorders. Central research objectives are: (i) to establish innovative energy autonomous implants that allow a feedback-controlled electrical stimulation, (ii) efficient multi-scale simulation models to enable rapid progress in targeted implant improvements and patient-specific therapies, (ii) to analyse the basic mechanisms of electrical stimulation in bone, cartilage and brain, and to translate this knowledge into clinical practice. For this purpose, scientists from the fields of electrical engineering, computer science, mechanical engineering, material science, physics, biology, and medicine will work together in an interdisciplinary manner. As a unique characteristic, our interdisciplinary consortium enables a scientifically sound validation of newly derived theoretical models, computational methods and technical solutions through experiments in both engineering and the life sciences.

Doctoral researcher candidates will be members of ELAINE’s Integrated Research Training Group and profit from a number of qualification measures.

The CRC will start on July 1, 2017 and run until June 2021. The positions shall be filled as early as possible and will run until the end of the project.

Applications

For more information and to upload your application (CV, diploma and grade sheet documents, letter of interest and contact information for potential references) visit www.elaine.uni-rostock.de.

Deadline for application: individual dates according to the subproject

ELAINE partners

  • The University of Rostock, founded in 1419 in the Hanseatic town of Rostock, is the oldest university in the Baltic Sea Region. Today, it has 9 faculties and 14000 students. Under the motto ‘Traditio et Innovatio’ it founded an Interdisciplinary Faculty in which ELAINE is embedded in the two Departments ‘Life, Light & Matter’ and ‘Aging Science and Humanities’.

ELAINE is a project of the University of Rostock. Most positions are located at the University of Rostock and the Rostock University Medical Centre. Yet, renowned experts from three other universities joint our consortium such that some positions are located at the following partners

  • Ernst-Moritz-Arndt University of Greifswald
  • University of Leipzig
  • Friedrich-Alexander University of Erlangen-Nürnberg

ELAINE projects

Details about ELAINE partners and projects

A01 – ‘Domain-specific languages for developing multi-scale, spatio-temporal biochemical models and their application’

Doctoral researcher position (pay scheme 100% TV-L E13) (University of Rostock) (position filled)

The objectives refer to i) developing multi-scale spatio-temporal biochemical models and executing simulation studies to analyse cellular responses to electrical stimulation, and ii) studying and refining domain specific languages for modelling and executing spatio-temporal simulation studies. Based on multi-scale spatio-temporal models and in close cooperation with the team of Prof. Nebe (A03) and Prof. Storch (C04), the impact of electrical implants on membrane-related, intra- and inter-cellular dynamics, and central cellular functions like differentiation shall be studied. For developing such models and executing individual in-silico experiments and even entire simulation studies effectively, domain-specific languages play an increasingly important role. The methodological research aims at exploring this role for multi-scale spatio-temporal simulation studies more deeply, at advancing multi-scale spatio-temporal modelling languages and their efficient execution, and at refining spatio-temporal logics for an effective model-based checking of trajectories. The methodological work will be done in close cooperation with the team of Prof. van Rienen (A02).

Requirements: The preferred candidate should have

  • an excellent master’s degree in computer science, mathematics or physics,
  • an interest for interdisciplinary research and medicine,
  • the ability to work in new topics as well as an independent way of working and being proactive.
  • Interest/experiences in modelling and simulation, formal language and algorithm design, and statistics.
  • very good programming skills

Good command of the English Language and good English writing skills are mandatory.

For additional information please contact:

Prof. Dr. Adelinde Uhrmacher

adelinde.uhrmacher@uni-rostock.de

 

A02 - ‘Multi-scale models for studies on electrically active implants in due consideration of uncertainties in the input data’

Post Doc position (pay scheme 100% TV-L E13) (University of Rostock) (position filled)

The objective is two-fold: (i) uncertainty quantification for inter-individual variations from patient to patient and during the therapy: Analyse the mechanisms of action of electrical stimulation therapy used for the treatment of dystonia and bone growth and compute the most advantageous stimulation parameters considering the patient-individual properties and condition, i.e. considering uncertain model parameters and their propagation in the models; (ii) acquisition and coordination of a collection of multi-scale modelling models for the simulation of bone, cartilage and deep brain stimulation: Select and implement appropriate multi-scale models that allow to tackle different simulation approaches on a single level, such as finite element models or equivalent circuits, and facilitate incorporation of homogenisation approaches and interface modelling for the transfer of microscopic results to the macroscopic level.

The postdoctoral researcher will work very closely together with two doctoral researchers studying the respective single scale models in the same project A02 and with the team of Prof. Uhrmacher (project A01). Validation of the chosen modelling and simulation approaches is achieved together with project A01 and experimental cooperation partners from several other projects of the CRC.

Requirements:

  • The preferred candidate should have an excellent doctoral degree in mathematics, computational (science and) engineering, electrical engineering, biomedical engineering or physics, an interest for interdisciplinary research and medicine, the ability to work in new topics as well as an independent way of working and being proactive.
  • Excellent knowledge in programming is expected.
  • Experience in numerical simulation/modelling is expected; experience in statistics and multi-scale modelling is highly welcome.
  • Good command of the English Language and good English writing skills are mandatory.

Doctoral researcher position (1) (pay scheme 100% TV-L E13) (University of Rostock) (position filled)

The objective is to contribute to the conception of an electro-stimulative implant system for the regeneration of cartilage. This project will focus on microscopic models while another CRC project will provide in vitro validation experiments and cover macroscopic numerical models. Concurring theoretical and numerical models exist, so a first step will consist in examining the appropriateness of selected models. The selection of essential electrical, mechanical and chemical processes, their suitable microscopic modelling as well as the particularisation of experimentally gained model parameters from the partnering project ‘Electrical and mechanical stimulation of hyaline cartilage: Characterisation of biological response and stimulation parameters’ will be tackled. Together with the post-doctoral researcher in project A02 and project ‘Dielectric characterisation of cells, tissues and materials’, uncertainties in the dielectric properties of cartilage shall be accounted for.

Requirements:

  • The preferred candidate should have an excellent master’s degree in computational (science and) engineering, electrical engineering, biomedical engineering, mechanical engineering, mathematics or physics, an interest for interdisciplinary research and medicine, the ability to work in new topics as well as an independent way of working and being proactive.
  • Excellent knowledge in the numerical solution of partial differential equations and in programming is expected.
  • Basic knowledge in statistics is highly welcome.
  • Good command of the English Language and good English writing skills are mandatory.

Doctoral researcher position (2) (pay scheme 100% TV-L E13) (University of Rostock) (position filled)

The objectives are to develop a computational model pipeline for deep brain stimulation in a hamster and supporting the animal experiments in project C03 by predicting sets of promising stimulation parameters and electrode geometries to improve the stimulation success. The close relation between the computational model and the experimental setup will enable an efficient investigation of the mechanisms of action of deep brain stimulation in the animal model by isolating inefficient stimulation parameters and electrode geometries prior to the experiments. In addition, it should facilitate a direct validation of the predicted stimulation parameters by project C03, which in turn will improve the accuracy of the computational model.

This will permit computing the activation in the target area during stimulation as well as determining possible side effects by the stimulation of non-target areas.

Finally, in close cooperation with the Post Doc in A02 and the partner project A05, a realistic model of the dielectric tissue properties shall be established and the statistical uncertainty in the neuronal and tissue properties shall be incorporated into the computational model.

Requirements:

  • The preferred candidate should have an excellent master’s degree in computational (science and) engineering, electrical engineering, biomedical engineering, mechanical engineering, mathematics or physics, an interest for interdisciplinary research and medicine, the ability to work in new topics as well as an independent way of working and being proactive.
  • Excellent knowledge in the numerical solution of partial differential equations, segmentation and CAD modelling of imaging data, and in programming is expected.
  • Basic knowledge in statistics is highly welcome.
  • Good command of the English Language and good English writing skills are mandatory.

For additional information please contact:

Prof. Dr. Ursula van Rienen

ursula.van-rienen@uni-rostock.de

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A03 – ‘Material surface charges and their influence on cell physiology and morphology’

Doctoral researcher position (1) (pay scheme 65% TV-L E13) (Rostock University Medical Centre) (position filled)

The project addresses the question of how the surface feature of materials influences cellular behaviour at the material interface in vitro. In particular we intend to determine how the material’s surface charge in combination with the electrical field affects the initial cell adhesion processes, cell morphological processes, migration, cell signalling and the gene expression of proteins relevant to adhesion. In detail, we want to shed light on the surface charge dependent regulation of intracellular calcium signalling.

The doctoral researcher closely works together with: A04 concerning the adjustment of the surface charge via specific chemical functionalisation, the simulation projects concerning wet lab validation of few selected simulation experiments, and B01 and C01 concerning materials for bone regeneration and analysis of bone cells.

Requirements:

  • The preferred candidate should have an excellent master’s degree in biology, biological sciences, medicine, biochemistry or cell biology, an interest for interdisciplinary research, the ability to work in new topics as well as an independent way of working and being proactive.
  • Excellent knowledge in cell biology, cell culture techniques, cell biological and molecular analysis (e.g. FE-SEM, LSM, FACS) is expected.
  • Basic knowledge in statistics is necessary.
  • Good command of the English Language and good English writing skills are mandatory.

For additional information please contact:

Prof. Dr. J. Barbara Nebe

barbara.nebe@med.uni-rostock.de

Doctoral researcher position (2) (pay scheme 65% TV-L E13) (University of Rostock)

The initial phase of osteoblast adhesion on surfaces is influenced by a variety of parameters such as surface charges, electric fields and electromagnetic fields. The aim of the project is to elucidate the role, the interplay, and the effect of the localization of such parameters on cell biology. Our experimental approach is Scanning Ion Conductance Microscopy (SICM), which allows to acquire the nanomorphology and relative ion concentration of live cells and their local environment.

The research program of the group Physics of Surfaces and Interfaces is dedicated to unravel mechanisms and processes relevant in the coupling of solid, chemical, and biologic structures on the nanometre scale. Respective investigations require scanning probe microscopy (SPM) based approaches and their correlation with optical and electron spectroscopy.

Requirements:

  • The position requires a master’s degree in physics or a related discipline from a university, preferentially experience in experimental research of nanostructures or biophysics.
  • Good command of the English Language and good English writing skills are mandatory.

For additional information please contact:

Prof. Dr. Sylvia Speller

sylvia.speller@uni-rostock.de

 

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A04 – ‘Electrically conductive multilayers for implant surfaces’

PhD position (pay scheme 65% TV-L E13)(Ernst-Moritz-Arndt University of Greifswald) (position filled)

The project aims to understand and eventually to control the reaction of cells to electro-stimulation. Many cells are to be exposed simultaneously to the same time-dependent electric field. Cells will grow on large (centimetre-squared) flat surfaces, which will be functionalised with ultrathin electrically conductive multilayer films. These films are prepared by sequential adsorption of oppositely charged macromolecules and electrically conductive nanoparticles, with the adsorption sequence of the different composites determining the properties of each film.

The doctoral researcher closely works together with: A03 and C04 concerning the in vitro stimulation of neural stem /progenitor cells, with A03 concerning characterization of surface charge and homogeneity, for selected simulation experiments and web lab validation with A02.

Requirements:

  • The preferred candidate should have an excellent master’s degree in physics, chemistry, materials science or similar field, an interest in interdisciplinary research, the ability to work independently, and also in new subject areas.
  • Excellent knowledge in characterization techniques (X-ray reflectivity, AFM: imaging and surface forces, electric conductivity) and data analysis, as well as sample preparation.
  • Good command of the English Language and good English writing skills are desirable.
  • For additional information please contact:

Prof. Dr. Christiane A. Helm

helm@greifswald.de

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A05 - 'Dielectric characterisation of cells, tissue and materials'

Doctoral researcher position (pay scheme 100% TV-L E13) (University of Rostock) (position filled)

Knowledge of the dielectric properties of tissues at interfaces with implants is crucial for the understanding of the response to electrical stimuli. The objective of the project is their characterization in particular for bone tissues and for interfaces with bone implants using dielectric spectroscopy. The goal is a comprehensive description of implantation and osseointegration with respect to patient-specific differences and implant properties. Ideally dielectric spectroscopy methods can be developed to monitor patient progress. Overall topic of the doctoral research is the development of appropriate dielectric methods and procedures, conduct of respective experiments and the analysis of results.

In the course of the project and in close cooperation with A02 models will be developed that are based on the dielectric analysis and allow describing inter-individual variations from patient to patient. Cell attachment, cell growth and cell differentiation will be evaluated for different stimulation parameters. With the dielectric characterisation of implant surfaces and coatings that are developed in close cooperation with B05 a complete description of the implant process by equivalent circuit models is anticipated. The doctoral researcher will work closely and interdisciplinary with other cooperation partners across ELAINE and with researchers already engaged in dielectric spectroscopy studies. Cell culture and biological protocols will be supported accordingly.

Requirements:

  • The preferred candidate should have an excellent master’s degree in physics, biophysics, electrical engineering, biomedical engineering or any closely related field.
  • Interest for interdisciplinary research and medicine, the ability to proactively develop new topics and ideas as well as an independent way of working.
  • Ideally experience in the development of numerical models and circuit models (e.g. using MATLAB). Experience in statistical data analysis and programming skills are welcome.
  • Previous experience in dielectric spectroscopy and/or experience with cell culture are welcome.
  • Good command of the English Language and good English writing skills are mandatory.

For additional information please contact:

Prof. Dr. Juergen Kolb

juergen.kolb@uni-rostock.de

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B02 - ‘Transformation of mechanical energy as internal energy source for electrically active implants’

Doctoral researcher position (1) (pay scheme 100% TV-L E13) (Rostock University Medical Centre) (position filled)

The two main research questions addressed in B02 are: how to use mechanical energy from load-bearing implants for conversion into electrical energy; and how to integrate electronic components into such implants without compromising the mechanical safety. Therefore, finite-element-analyses need to be carried out in combination with design and optimization towards the placement of electrodes and the placement of electronic components like sensors, energy-harvesting-elements and telemetry units. Experimental tests will be conducted on functional models to validate the performance in terms of electrical conversion as well as mechanical fatigue.

The doctoral researcher closely works together with: B03 with regard to choice of the energy harvester and energy consumption, A02 and C01 concerning placement of electrodes, and B05 with regard to bioactive piezoelectric structures and mechanical behaviour.

Requirements:

  • The preferred candidate should have an excellent master’s degree in engineering, with focus on mechanical engineering, biomechanics or biomedical engineering
  • Experience in numerical simulation using finite element methods is essential
  • Experience in mechanical testing and fatigue testing is expected.
  • Basic knowledge of electrical engineering and energy harvesting is expected.
  • The candidate is expected to work independently and to enjoy working in an interdisciplinary field
  • Good command of the English Language and good English writing skills are mandatory.

For additional information please contact:

Priv.-Doz. Dr.-Ing. Daniel Klüß

daniel.kluess@med.uni-rostock.de

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B03 – ‘Energy-autonomous platform for electrical stimulation implants’

Doctoral researcher position (2) (pay scheme 100% TV-L E13)(University of Rostock) (position filled)

The objectives is to develop a power supply system for medical implants. Thermoelectric energy harvesting from the human body will be employed to extend the operation time of battery-powered implants as used in e.g. deep brain stimulation. A thermoelectric power generator relies on the presence of a temperature gradient across the body tissue. Therefore, comprehensive understanding of the temperature distribution in typical implant locations has to be acquired during the initial phase. Numerical modelling of bioheat transfer is an essential tool to consider various thermal effects such as metabolic and perfusion heat sources. The candidate will also work towards an advanced implant housing, which enables the integration of thermoelectric power generators. Existing titanium housings will be adapted in such a way as to achieve good thermal coupling between the generator and the surrounding tissue; simultaneously the housing shall be thermally isolated from the generator itself. The implant will contain the generator, power management electronics and the control circuitry. The candidate will collaborate with the projects C01, C03 and C04 in order to identify the electrical power requirements of the respective electrical activation schemes. Suitable power management electronic modules will also be evaluated and selected. In cooperation with the other Doctoral researcher and the postdoctoral researcher of B03 the interaction of the energy harvesting system and the SDIP will be analysed. Towards the end of the project, an integrated prototype will be assembled and thoroughly tested.

Requirements:

  • The preferred candidate should have an excellent master’s degree in electrical engineering, biomedical engineering, computational (science and) engineering, mechanical engineering or physics, an interest for interdisciplinary research and medicine, the ability to work in new topics as well as an independent way of working and being proactive.
  • Excellent knowledge in one or more of the following areas is expected: energy harvesting, thermoelectricity, bioheat transfer, ultra low power management or thermal modelling.
  • Good command of the English Language and good English writing skills are mandatory.

For additional information please contact:

Prof. Dr. Dennis Hohlfeld
dennis.hohlfeld@uni-rostock.de

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B05 – ‘Assessment of the mechanical reliability of porous and functionally graded implant structures by local damage approach’

Doctoral researcher position (pay scheme 100% TV-L E13)(University of Rostock) (position filled)

The objective of this project is to guarantee the mechanical reliability for implants, with respect to both the limit load behaviour and the fatigue strength. In project B05, the local damage and failure mechanisms as well as the appropriate prediction concepts for functionally graded porous structures produced by the additive manufacturing process of electron beam melting (EBM) will be investigated. For this, experiments with porous basic structures will be performed under quasi-static and fatigue loading. Herein not only axial loading, but also bending and shear loading will be investigated, in particular. On the basis of these fundamental experiments, the topology of the basic structures will be mechanically optimised. Moreover, a functional gradation of the stiffness for a better osseointegration will be investigated with respect to the limit load and fatigue behaviour and tested under compression, bending and shear loading. For the development of mechanism-based concepts for the assessment of the mechanical reliability of porous structures, complex finite element analyses will be performed in order to detect the damage mechanism. The results will be exemplarily applied to solid implants, which will be build-up as porous structures.

Requirements:

o Scientific Master degree with focus on structural mechanics with excellent gradings

o Excellent knowledge in finite element simulations

o Excellent knowledge in fatigue of metallic materials and/or limit load behaviour

o Knowledge in planning, performing and evaluating of experiments

o Interest for interdisciplinary science and medicine

o Ability to develop new approaches

o Capacity for teamwork

o Willingness to travel

o Excellent knowledge in German and English language are mandatory

For additional information please contact:

Prof. Dr. Manuela Sander

manuela.sander@uni-rostock.de

 

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C01 – ‘Electrical stimulation of osseoinduction using alloplastic reconstruction plates after mandibular segmental resection’


Doctoral researcher position (1) (65%) (Rostock University Medical Centre) 

This project is focused on regeneration of larger defects of the bony mandible via electric stimulation. Based on previous research in the literature as well as from our group on electrically active implants, we hypothesise that bioactivation of mandibular reconstruction plate systems via electrical stimulation is a possibility to regenerate the lack of surrounding bone without the need for secondary bone transplantation.  Accordingly, in the first part of this project, electronically active components of a custom-made reconstruction system will be tested in vitro using osteogenic stem cells. Afterwards, an implantable device for endogenous stimulation of osseous regeneration will be used in combination with a mandibular reconstruction plate system together with the respective osteogenic stem cells in order to bridge a critical size defect in mini-pigs. The potential of the device for osseous stimulation will be evaluated using this demanding large-bony-defect model with a physiology similar to humans.

Together with other members of the research group, the doctoral researcher requested for this project will carry out in vitro cellular as well in vivo animal studies on the effects of the influence of electric stimulation on osteogenesis. Together with the support and supervision by the group members, these studies including his or her doctoral thesis are able to be finished within the project phase.

Requirements:

  • The candidate should have an excellent degree in biology, biotechnology, medicine or related subjects, an interest for interdisciplinary research, the ability to work in new topics as well as an independent way of working and being proactive.
  • Excellent knowledge in cell biology, cell culture techniques, cell biological and molecular analysis (e.g. PCR, SEM, LSM) is expected.
  • Pleasure in experimental work
  • It is advantageous that the preferred candidate has experiences with cellular and/or animal studies.
  • Basic knowledge in statistics is necessary.
  • Good command of the English Language and good English writing skills are mandatory.

For additional information please contact:

PD Dr. med. habil. Dr. med. dent. Peer Kämmerer
peer.kaemmerer@med.uni-rostock.de

 

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C02 – ‘Electrical and mechanical stimulation of hyaline cartilage: Characterisation of biological response and stimulation parameters’

Doctoral researcher position (1) (65%) (Rostock University Medical Centre) (position filled)

The combined electrical and mechanical stimulation of cartilage cells can be a promising approach for cartilage repair by inducing different cellular mechanism supporting hyaline-like differentiation of cells. Within project C02 a special stimulation device for the single and combined stimulation of cells will be developed to enhance the in vitro cultivation and hyaline-like differentiation of chondrocytes and MSCs. Doing this, suitable implant materials for the targeted application of mechanical load and electric fields will be investigated. Studies will be performed using murine collagen gel scaffolds as well as bioplotted hydrogel scaffolds consisting of a novel composites provided by project B01.

Requirements:

  • The candidate should have an excellent degree in biology, biotechnology, medicine or related subjects, an interest for interdisciplinary research, the ability to work in new topics as well as an independent way of working and being proactive.
  • Excellent knowledge in cell biology, cell culture techniques, cell biological and molecular analysis (e.g. PCR, SEM, LSM) is expected.
  • Basic knowledge in statistics is necessary.
  • Good command of the English Language and good English writing skills are mandatory.

For additional information please contact:

Prof. Dr. Rainer Bader

rainer.bader@med.uni-rostock.de

 

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C03 - ‘Deep brain stimulation in dystonia models: Biological implementation, approximation of stimulation parameters and analysis of mechanisms’

Post Doc position (pay scheme 100% TV-L E13) (Rostock University Medical Centre) (position filled)

Dystonia affects around three million people worldwide, being the third most common movement disorder. Drug therapy is unsatisfactory especially in generalised dystonia. A relatively new treatment option is deep brain stimulation (DBS), for which three key questions remain unresolved: How does DBS act on the basal ganglia network, and why only after such long latency? Which stimulation parameters are optimal, and do they depend on the type of dystonia? Are there any electrophysiological biomarkers that allow prediction of therapeutic success? These questions define the aims of the project, which is jointly carried out by cooperating groups in Rostock and Leipzig. General aims for the work of the Post Doc: (A) Analyse the mechanisms of action of DBS (synaptic / structural plasticity, modulation of inhibition, pathological oscillations, neurochemistry, electrical field propagation modelling) in brain slices in vitro (B) Identify biomarkers predicting outcome (EEG spectra, evoked potentials, PET imaging of basal ganglia) in vivo.

Requirements:

  • The candidate should have an excellent degree in medicine, biology or related subjects, and should hold a Doctoral researcher, MD or equivalent in a similar field.
  • Further, we expect the candidate to do in vivo animal experiments, parallel to in vitro brain slice electrophysiology. In this context, experience with electrophysiological techniques is essential.
  • The candidate is expected to be interested in interdisciplinary work, to work independently and to enjoy finding creative solutions
  • We expect a good command of the English language (oral and written)

For additional information please contact:

Prof. Dr. Rüdiger Köhling

ruediger.koehling@med.uni-rostock.de

 

Doctoral researcher position (pay scheme 65% TV-L E13) (University of Leipzig)

The general aim of the work of the doctoral researcher position is to (A) approximate stimulation parameters in animal models of dystonia by in vivo experiments (stimulus patterns, target structures, parameter modelling) and as a secondary aim, together with the group in Rostock, to (B) identify mechanisms and biomarkers as therapeutic predictors (e.g., immunohistochemistry, EEG).

Requirements:

  • The candidate should have an excellent degree in medicine, biology or related subjects.
  • Experience with in vivo rodent experiments is of advantage.
  • The candidate is expected to be interested in interdisciplinary work, to work independently and to enjoy finding creative solutions.
  • Good communication and scientific writing skills in English are expected.

For additional information please contact:

Prof. Dr. Angelika Richter

angelika.richter@vetmed.uni-leipzig.de

 

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C04 - ‘Effects of deep brain stimulation on adult neurogenesis in a rat model of Parkinson’s disease: Mechanisms of action, stimulation parameters and correlation with behaviour’

Post Doc position (pay scheme 100% TV-L E13) (Rostock University Medical Centre) (position filled)

The objective is to dissect the regulatory mechanisms underlying the effects of deep brain stimulation on adult neurogenesis. This subject area is divided into an (A) in vivo and an (B) in vitro part. The (A) in vivo part is two-fold: The impact of (i) direct electrical stimulation of stem/progenitor cells within their neurogenic niches versus (ii) indirect regulation of stem cell activity via neuronal networks and neurotransmitter systems. The exploration of the first mechanism needs a strong interplay with the team of Prof van Rienen and Dr Schmidt (project A02 ‘Multi-scale models for studies on electrically active implants in due consideration of uncertainties in the input data’), because the electrical field distribution within the brain tissue from the respective modelling/simulation is needed. The second mechanism of indirect stimulation of neurogenesis via neuronal networks and neurotransmitter systems will be analysed by histological network analysis and pharmacological approaches to influence the neurotransmitter systems. Major input for this approach will come from the van Rienen/Schmidt group (A02) on the volume of tissue activated coming from the simulations of the electrical field distribution within the brain tissue leading to hypothetical networks activated by deep brain stimulation. The network analyses as well as microdialysis will be done in close collaboration with the Köhling/Richter group (project C03 ‘Deep brain stimulation in dystonia models: Biological implementation, approximation of stimulation parameters and analysis of mechanisms’). The (B) in vitro part aims to understand the cellular and molecular mechanisms mediating the effects of electrical stimulation on adult neural progenitor cell behaviour under the standardised conditions of a cell culture system. In close cooperation with the Helm group (project A04 ‘Electrically conductive multilayer films for implant surfaces’), special composites as cell culture surfaces will be used to electrically stimulate the progenitor cells. Studies on neural stem/progenitor cell adhesion, morphology and migration will be conducted in cooperation with the Nebe/Speller group (project A03 ‘Material surface charges and their influence on cell physiology and morphology’) and the Bader/Seitz group (project C02 ‘Electrical and mechanical stimulation of hyaline cartilage: characterisation’).

Requirements:

  • The preferred candidate should have an excellent doctoral degree in in veterinary medicine, human biology, biology, biochemistry or related natural sciences, an interest for interdisciplinary research and medicine, the ability to work in new topics as well as an independent way of working and being proactive.
  • Experience in (cellular) neurosciences is expected; experience in statistics is highly welcome.
  • Good command of the English Language and good English writing skills are mandatory.

Doctoral researcher position (pay scheme 65% TV-L E13) (Rostock University Medical Centre) (position filled)

The Experimental Neurology group explores mechanisms underlying neurodegenerative diseases, such as Parkinson’s disease. We use translational approaches to improve reinnervation of destroyed dopaminergic pathways. Deep brain stimulation is an invasive therapeutic option for patients with Parkinson’s disease but the mechanisms behind it are not yet fully understood. The objective is to contribute to the development of regenerative medicine for Parkinson's disease. The doctoral researcher requested for this project will carry out in vivo animal studies on the effects of Deep brain stimulation on adult neurogenesis including behavioural tests in the animal model of the rat. Together with the support and supervision by the group members, these studies including his or her doctoral thesis are able to be finished within the project phase.

Requirements:

  • The preferred candidate should have an excellent master’s degree in veterinary medicine, human biology, biology, biochemistry or related natural sciences, an interest for interdisciplinary research and medicine, the ability to work in new topics as well as an independent way of working and being proactive.
  • Pleasure in experimental work.
  • It is advantageous that the preferred candidate have experiences with animal studies.
  • Basic knowledge in statistics is highly welcome.
  • Good command of the English Language and good English writing skills are mandatory.
  • For additional information please contact:

Prof. Dr. Alexander Storch

alexander.storch@uni-rostock.de

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IRTG - ‘Integrated Research Training Group’
Short-term Research Fellowships (position filled)

Every year, the Integrated Research Training Group (IRTG) of the DFG Collaborative Research Centre (CRC) 1270 ‘Electrically Active Implants’ – ELAINE offers short-term research fellowships for up to one year. These fellowships give young researchers the opportunity to spend working in optimal conditions on a theme broadly related to the interdisciplinary framework of the CRC ELAINE. Among other opportunities, fellows will have the possibility to participate in a highly interdisciplinary and collaborative research programme and to develop their knowledge and skills under the active supervision of the project leaders of the CRC. The payment depends on the target group (please check below) according to the maximum rates recommended by the DFG.

Requirements:

  • Short-term fellowships are available to:
  1. PhD candidates – to realize own project proposals or to be admitted from abroad
  2. students of medicine holding their first state examination – to improve incentives to doctorate,
  3. and those who hold other terminal degrees (university of applied sciences degree, polytechnic degree, bachelor's degree)  – to qualify for admission to doctorate

Good command of the English Language and good English writing skills are mandatory.

For additional information please contact:

Prof. Dr. Alexander Storch
alexander.storch@uni-rostock.de

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INF – ‘Infrastructure Support Project’

PostDoc Position (pay scheme 100% TV-L E13) (University of Rostock) (position filled)

The objective is the conception and realization of research data management, e.g. for numerical simulations, imaging techniques or experiments, for the entire collaborative research centre. Herby an explicit focus lies on the support of open and reproducible research. This includes the realization of a virtual research environment for the CRC respectively the University of Rostock. Research in the field of efficient management of research data and the reproduction of scientific results should be carried out. The candidate is furthermore responsible for a training and qualification programme on data management. The postdoctoral researcher will work very closely together with all research projects of the CRC as well as with the university library for long-term preservation of data.

Requirements:

  • Excellent doctoral degree in computational (science and) engineering, electrical engineering or physics
  • Interest for interdisciplinary research and medicine
  • Ability to work in new topics as well as an independent way of working and being proactive
  • Excellent knowledge in electronic data processing is expected
  • Experience with open and reproducible science as well as the design of data structures is expected
  • Good command of the English Language and good English writing skills are mandatory.

 

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IMPRS SurMat
IMPRS SurMat
Standort: Duesseldorf, Deutschland | Bewerbungsschluss am Aug. 31
PhD positions at the International Max Planck Research School SurMat - Interface Controlled Materials for Energy Conversion
PhD positions are currently available on computational and experimental projects. Our structured, three-year doctoral programme, conducted entirely in English, takes an intensive interdisciplinary approach and brings together scientists from across the globe in the Rhine-Ruhr...
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Leibniz-Institut für Polymerforschung Dresden (IPF)
Leibniz-Institut für Polymerforschung Dresden (IPF)
Standort: Dresden, Deutschland | Bewerbungsschluss am Sep. 14
PhD position (Research Associate) - Visualizing particle motion in flowing dense suspensions
Job vacancy No. 104-2018 The IPF-Institute of Physical Chemistry and Polymer Physics, Department of Polymer Interfaces, is offering one PhD position (Research Associate) funded by the Deutsche Forschungsgemeinschaft (DFG) starting date can be as soon as possible, for a...
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Fraunhofer IMWS, Hallen
Fraunhofer IMWS, Hallen
Standort: Halle, Deutschland | Bewerbungsschluss am Aug. 31
WISSENSCHAFTLICHE MITARBEITERIN / WISSENSCHAFTLICHER MITARBEITER ANALYSEVERFAHREN – BIG DATA
FRAUNHOFER-INSTITUT FÜR MIKROSTRUKTUR VON WERKSTOFFEN UND SYSTEMEN IMWS PHOTOVOLTAIK IST IHR THEMA? WIR BEI FRAUNHOFER BIETEN IHNEN AB 01.10.2018 EINE SPANNENDE TÄTIGKEIT ALS WISSENSCHAFTLICHE MITARBEITERIN / WISSENSCHAFTLICHER MITARBEITER  ANALYSEVERFAHREN – BIG...
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Fraunhofer IPT, Aachen
Fraunhofer IPT, Aachen
Standort: Aachen, Deutschland | Bewerbungsschluss am Dez. 31
WISSENSCHAFTLICHE MITARBEITERIN / WISSENSCHAFTLICHER MITARBEITER TECHNOLOGIEORGANISATION
FRAUNHOFER-INSTITUT FÜR PRODUKTIONSTECHNOLOGIE IPT TECHNOLOGIEORGANISATION IN ZEITEN VON INDUSTRIE 4.0 IST GENAU IHR THEMA? VERSTÄRKEN SIE UNSER TEAM ALS WISSENSCHAFTLICHE MITARBEITERIN / WISSENSCHAFTLICHER MITARBEITER  TECHNOLOGIEORGANISATION Bei uns...
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Fraunhofer IIS, Erlangen
Fraunhofer IIS, Erlangen
Standort: Erlangen, Deutschland | Bewerbungsschluss am Dez. 31
ENTWICKLUNGSINGENIEURIN / ENTWICKLUNGSINGENIEUR MOBILKOMMUNIKATION 5G / V2X
FRAUNHOFER-INSTITUT FÜR INTEGRIERTE SCHALTUNGEN IIS WIR AM FRAUNHOFER-INSTITUT FÜR INTEGRIERTE SCHALTUNGEN IIS IN ERLANGEN BIETEN IHNEN ZUM NÄCHSTMÖGLICHEN ZEITPUNKT EINE SPANNENDE TÄTIGKEIT IN UNSEREM BEREICH »KOMMUNIKATIONSSYSTEME« ALS ENTWICKLUNGSINGENIEURIN...
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